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Taken together, we speculate that in the three-spot wrasse, DMRT1 was up-regulated in the presence of AI, presumably due to changes in the proportion of germ cell types in the testis.
In addition, proliferation occurs in a variable proportion of germ cells throughout perinatal life.
However, the lack of survival improvement in young women may only be partially explained by the higher proportion of germ cell tumours compared with the older cohorts.
VASA immunopositive germ cells were detected from 14 weeks' gestation in the marmoset and in an increasing proportion of germ cells as gestation progressed.
RNAi or genetic depletion of IFG-1 p170 (long eIF4G, Figure 1) alone amplifies the natural proportion of germ cell apoptotic events in differentiating oocytes [ 71].
The recurrence risk is increased after the birth of two affected individuals, presumably because the proportion of germ cells that carry the mutation is higher.
Similar(44)
Our experimental measurements of gene expression levels constitute bulk expression estimates from heterogeneous samples containing various proportions of germ and somatic cells.
Consistent with a previous study (Anderson et al., 2007), no expression of VASA was detected in germ cells in testes in the first trimester (not shown), but VASA immunopositive germ cells were detected in second trimester testes, with increasing proportions of germ cells expressing VASA in the third trimester (Fig. 3).
Increasing proportions of germ cells contained immunopositive staining in their nucleus during the final third of gestation and by early postnatal life most of the germ cells contained NANOS-1, with localization of the protein to both the nucleus and peri-nuclear cytoplasm (Fig. 6).
Consistent with previous reports, OCT4 (Fig. 2), NANOG and AP-2γ (not shown) were detected in most testicular germ cells of first trimester fetuses but the proportion of immunopositive germ cells decreased as gestation progressed (Looijenga et al., 2003; Gaskell et al., 2004; Honecker et al., 2004; Rajpert-De Meyts et al., 2004; Pauls et al., 2006; Kerr et al., 2008).
Neither of these animals was the one referred to above with an unusually high proportion of OCT4+ germ cells.
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