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Among molecular functions, the largest proportion of functionally assigned ESTs were in nutrient reservoir activity (GO 0045735, 40.6%), nucleotide binding (GO 0000166, 26.5%) and structural molecule activity (GO 0005198, 6.4%); the first two classes accounted for 67.1% of assignable GO terms.
Considering both the number and the proportion of functionally characterized genes in Arabidopsis, it seems that the functional characterization of rice genes is far from complete.
The results also endorse that UEHGs may contain a large proportion of functionally essential genes.
Nevertheless, this method predicted a higher proportion of functionally important residues in the membrane than outside (Supplemental Table 5).
Significant differences in the proportion of functionally annotatable singletons between runs were tested with KS tests in R (www.r-project.org, last accessed April 2013).
The largest proportion of functionally assigned ESTs fell into protein metabolism (11%) and transport (8%) except of unknown biological processes (20%) and other cellular processes (14%).
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To examine how functional conservation changes over time, we compared proportions of functionally conserved duplicates between pairs of sister species separated by varying evolutionary distances (Fig. 1b).
Relationship of median K a between pairs of species (humanchimpanzee, human-gorilla, human-orangutan, human-macaque, human-mouse, human-opossum, human-platypus, and human-chicken) to proportions of functionally conserved single-copy (black) and duplicate (red) genes.
Many proteins belonging to the overlapping proteomes of ATCC 700755T and ACAM 44T were readily detected, as expected, as were high proportions of functionally conserved, mainly cytosolic proteins (fig. 4).
These results confirm that the evolutionary differences observed between dominant and recessive disease genes are due to different selective pressures acting on these two sets of genes during their history and not simply due to varying proportions of functionally dissimilar genes in each group.
It should be stressed that, since many of the tests were performed on heterozygous flies, the proportion of genes functionally involved in oxidative stress resistance may be higher.
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