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The proportion of foci containing large numbers of TCS domains are similar between bacteria and myxobacteria (data not shown).
For example one might assess the number of different TCS gene organisations within a replicon, or the proportion of foci with > n genes.
In the STZ + DMH group, the proportion of foci containing ≥3 crypts was 34.87%, a value higher than that containing 2 crypts (28.68%).
If so, we would expect that for any number of encoded domains, the proportion of genes containing T, R or P domains, would be similar to the proportion of foci containing those domains (Tables 3 and 4).
Similar(56)
The proportions of focused and non-focused information within a discourse are subject to constant dynamics.
It is important to note that, whereas all TRF2 foci in U2OS cells contained SLX4, a proportion of SLX4 foci did not overlap with TRF2.
Furthermore, SLX4 foci in A549 cells and HeLa cells are considerably less intense than in U2OS cells, but a significant proportion of the foci still colocalized with TRF2.
In addition, the proportion of the foci containing a different number of crypts was changed (Fig. 2).
Co-localization was only detected in a small proportion of RNA foci, suggesting dynamic sequestration rather than irreversible binding.
We will roughly estimate these values, based on the proportion of labelled foci observable, as l = 0.5 N for 24 hr BrU exposure (half of observed mtDNAs being labelled) and l = 0.05 N for 2 hr BrU exposure (5% of observed mtDNAs being labelled).
Although a significant proportion of telomeric foci in these cells do not contain SLX4, when signal intensity along an arbitrary track in a single Z-section of the nucleus was quantitated, the peaks corresponding to SLX4 demonstrated reasonably good overlap with TRF1.
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