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In addition to toxicity tests, the potential for risk may be typically assessed using the proportion of dose estimated to penetrate through exposed skin [17].
The overall proportion of dose excreted in urine across AZD9773 cohorts was approximately 15% (Table 4).
A high proportion of dose investigating programmes (50/68) included trials labelled (in the opinion) as investigating efficacy, activity or immunogenicity in every age group concerned by development.
The proportion of dose excreted was calculated by dividing the amount excreted in the urine over all post-dose intervals by the midazolam dose administered, with a correction for molecular weight where applicable (midazolam MW 325.8).
Although infliximab use was associated with a high proportion of dose escalations, we also observed that it had the longest continuation, suggesting that patients on infliximab tended to increase their dose rather than switch to another medication.
Because we also considered the possibility that the mass of PCBs given was important, our second dose was set to 4 mg, with the individual congeners being assembled in the same relative proportion of dose 1.
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The proportion of doses taken on schedule (within 2 hours of prescribed dosing interval) ranged from 3%to97%7% (median, 34%; mean, 41%[24%%]) and was better when the parent vs the child instilled eye drops (46%[26%%] vs 23%[19%%]; P <.001).
Calculations included average adherence (proportion of prescribed doses taken), dosing errors (number of overdosing or underdosing events in 24 hours), and proportion of doses taken on schedule (doses taken within 2 hours of prescribed dosing interval).
Questions related to viral load (VL) on a bivariate level included proportion of doses taken in the previous 3 days and 6 months, caregivers' knowledge of prescribed dosing frequencies, and caregivers' reports of problems associated with medication administration.
The proportion of dose-specific genes increased with decreased absorbed dose.
The relative proportion of dose-related abstracts increased from a minimum of 2.4% in 2000 to a maximum of 11% in 2005.
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