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Below this region, in the rib meristem, the proportion of divisions with the cell plate at right angles to the axis increases, so that the cells tend to be oriented in files.
This parameter determines what proportion of divisions will be unequal.
When picophytoplankton grew in the model, a small proportion of divisions (∼10−8) produced mutants, of three different types.
To determine the proportion of divisions where asymmetric cell fates are established in the ISC lineage, we analyzed lineage markers in cells that recently underwent mitosis.
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Assuming the data is organized as a 2-level hierarchy, the intra-divisional correlation coefficient is the proportion of division-level variance out of the total variance for that division [ 25].
This study also raises the possibility that the apical complex may have an activity to promote self-renewal in a way other than the formation or the maintenance of cell polarity because overexpressed Par6 increases symmetric proliferative divisions without changing a proportion of asymmetric divisions (Costa et al. 2008).
However, with 30 pM nocodazole, the proportion of asymmetric divisions in proliferating APs increased to a level similar to control neurogenic divisions.
Nocodazole at 30 pM did not increase much the proportion of asymmetric divisions in neurogenic APs, showing that this nocodazole concentration mostly influences the division symmetry of proliferating APs.
Furthermore, our data indicate that a large proportion of cell divisions in low grade Urobasal tumors are associated with the basal membrane, possibly giving rise to asymmetrical divisions.
Another mechanism that could control the proportion of asymmetric divisions at the 8- to 16- cell transition is the size of the microvillus pole generated at the cell apex during the 8-cell stage (through intercellular contacts) and its inheritance during the next mitosis.
In mammals, the proportion of neurogenic divisions of APs increases throughout embryonic neurogenesis, which in the mouse goes from around E10 to E17.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com