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Our measure asks what proportion of distinct n-mers only occur once in a genome?
Interestingly, a significant proportion of distinct signatures from the four libraries matched to introns and intergenic regions, similar to the findings of previous transcript profiling analyses [ 47, 48].
Three main patterns of TDP-43 pathology are recognized in FTLD-TDP, based on the anatomical distribution, morphology, and relative proportion of distinct types of inclusions [ 6, 7].
The reduction in the small RNA complexity in nrpe libraries was minimal compared with prior reports of substantial reductions in an Arabidopsis rdr2 mutant (proportion of distinct = 0.04 or 0.05) (Table S1 ).
More importantly, the proportion of distinct small RNA reads was similar between wild-type and nrpe mutant libraries (median values 0.346 and 0.352, respectively), in agreement with the results from Mosher et al. (Table S1 ).
In regard to the detection of low abundance expressed genes, the proportion of tags greater than 100-fold was over 54% and the proportion of distinct clean tags which was greater than 100-fold was very small (1.82% and 1.92%), but there are more than 80% distinct clean tags with a ratio within 5-fold.
Similar(49)
Nevertheless, few studies had dissected the combinatorial genomic complexity posed by varying proportions of distinct CCL3L and CCL4L genes among individuals [40].
Variation in the relative proportions of distinct cell types provides valuable clinical information in its own right.
The proportions of distinct repeats assigned to six categories of size intervals (30 39, 40 59, 60 89, 90 149, 150 249, and >250 bp) reveal that the distribution of repeat sizes is variable among and within lineages (supplementary fig. S2, Supplementary Material online).
Furthermore, the total quantity and relative proportions of distinct bacterial species found in the colon differ between lean and obese individuals as well as between individuals with and without diabetes [ 32, 33].
For example, alterations in the length and positions of double bonds within the acyl chain of a lipid molecule can confer widely differing properties and suggest that specific proportions of distinct fatty acid classes may be necessary for optimum membrane function [ 48].
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