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Combining all antimicrobial CVCs, there was no significant difference in the proportion of colonized antimicrobial CVCs colonized with Candida species compared to colonized standard CVCs.
However, the proportion of colonized minocycline-rifampin CVCs colonized with Candida species was greater than that of colonized standard CVCs (OR 13.6 [95%CI 4.2-43.4]).
Combining all antimicrobial CVCs, the proportion of colonized CVCs that were colonized by coliforms was greater than that of standard CVCs (OR 2.38 [95%CI 1.10-5.15]).
Colonization pressure was estimated as the average of the daily proportion of colonized patients (number of patients colonized divided by number of patients in the unit on a given day) from the day of admission until the day before acquisition of the microorganism or until discharge if the patient did not acquire the microorganism [ 38].
Combining all antimicrobial CVCs, there was no significant difference in the proportion of colonized antimicrobial CVCs that were colonized by Staphylococcus aureus or coagulase-negative staphylococci compared to the corresponding fractions of colonized control CVCs.
In comparison, the proportion of colonized chlorhexidine-silver sulfadiazine CVCs specifically colonized with Acinetobacter species or diphtheroids was less than the proportion of similarly colonized standard CVCs.
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The proportion of all colonized minocycline-rifampin CVCs found to harbor Candida species was greater than the proportion of all colonized standard CVCs found to have Candida.
The proportion of coliform-colonized silver CVCs and minocycline-rifampin CVCs was greater than that of standard control CVCs.
Although a substantial proportion of patients become colonized with Candida sp. during a hospital stay, only few develop severe infection.
We identified a significant increase in the proportion of Candida species colonization among colonized minocycline-rifampin CVCs.
The proportion of HCWs being persistently colonized ranged from 1%to10%0%, and proportions of patient acquisitions resulting from persistently colonized HCW ranged from 10%to50%0%.
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