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However, a substantial proportion of cohort has spread all over the country during follow-up period.
The highest proportion of cohort studies was also found for PA.
The proportion of cohort patients with cardiovascular-related conditions or diabetes was higher for ACEI/HCTZ and ARB/HCTZ than for HCTZ or BB/HCTZ.
However, the overall proportion of cohort patients who consulted a dermatologist was lower (15.8% vs 23.9%, p<0.001) because the proportion of patients referred to a dermatologist by the GPs was lower (12.2% vs 38.3%, p<0.001; table 1).
We think that this is unlikely, as we know of no such systematic change in approach during the period of our study; moreover, the proportion of cohort patients who had transplantation fell steadily from 28% (n=13) in the 1990-1 sub-cohort to 14% (n=5) in the final (2002-3) sub-cohort.
Results were robust with respect to variation in most parameters of the model (e.g. rates of suicides, probability of spontaneous remission from PTSD, proportion of cohort with co-morbid depression, probability of delayed response to PTSD treatment, effectiveness of SSRI for treatment of depression and health state specific utility estimates).
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Figure 5 reports the proportion of cohorts that selected cost-effectiveness thresholds between $0 and $400,000 because a recent review of cost-effective research in the United States suggested that no single cost-effectiveness threshold is necessarily appropriate and that U.S. policy makers often use different thresholds for different policy issues [ 85].
In addition, approximately 94% of participants had total cholesterol levels above 4 mmol/l, similar to the current study (90.7% across all three cohorts), an alarming proportion of each cohort with lipid profiles above recommended ranges.
Further, the tool affords interactive exploration of the transition patterns to find proportions of cohorts in the dataset.
To make our assessment we investigated three key criteria: (i) the proportion of the cohort in which tumours stained positively for markers, (ii) the proportion of the cohort in which tumours stained more strongly for markers than the matched normal tissues, and (iii) the magnitude of overexpression in tumours.
This requires a large elderly cohort to be followed over a long time period to ensure that a significant proportion of the cohort develops Alzheimer's disease.
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