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The proportion of clustered MDR TB cases was analyzed as the number of clustered cases divided by the total number of culture-positive cases that occurred during the study period.
Recently, molecular epidemiologic studies, which estimate the proportion of clustered TB cases, have been used to support this hypothesis (5 ).
For each definition, we assessed whether the proportion of clustered and not clustered tRNAs differed significantly between core and peripheral sets using a χ test.
Although with some variation, the proportion of clustered P/A genes was indeed much higher on the chromosome arms (Additional file 8: Figure S2) as expected.
Univariable meta-regression analyses were carried out to determine the effect of the study design covariates on the proportion of clustered isolates.
We originally thought that because the genome sequences of some plant species such as papaya consist of fragmented scaffolds due to incomplete sequencing, the proportion of clustered genes may be underestimated.
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Univariable meta-regression analyses were conducted to assess the influence of study design and setting on the proportion of clustering.
As expected, we found that the proportion of clustering decreased with a greater number of MIRU-VNTR loci typed, with increasing TB incidence and with increasing maximum cluster size.
These studies usually report the proportion of cases that are clustered within the cohort and use this result to infer the relative proportions of clustered and unclustered cases in the community from which the cohort was drawn.
In addition, higher proportions of clustered cases were observed for low-band number patterns, which had the maximum cluster size and may indicate that the low-copy IS6110 patterns are not specific, even with the addition of spoligotyping.
According to previous citywide surveys of all patients who had cultures that were positive for TB, the proportions of clustered patients who had TB were 37% in 1991 and 32.4% in 1994 100, 11).
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