Sentence examples for proportion of alterations from inspiring English sources
Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats.
In fact, a high proportion of alterations identified were frameshift insertion or deletion mutations, which are typically observed in MSI cancers as a consequence of mismatch repair deficiency.
Our objectives were to determine whether tumors arising from the tongue had a distinct genetic landscape, if these differences were population specific or correlated with any epidemiological factors (e.g., gender), and to determine the proportion of alterations with therapeutic potential.
Monoclonal antibodies and lectins, carbohydrate-binding proteins which are highly specific for various carbohydrate moieties [ 18], are also commonly employed for the detection of abnormal structures and the proportion of alterations can be quantified [ 14, 19– 219.
Although some data indicate that the stromal compartment, when microdissected from human breast cancers, exhibits genetic alterations (Eng et al, 2009), the proportion of karyotypic alterations in fibroblasts remain less frequent than in cancer cells (Qiu et al, 2008).
Emerging evidence demonstrates that a significant proportion of these alterations are mediated by hormone imbalances.
A sizeable proportion of these alterations to host cell gene expression are under control of a viable parasite, as they are altered by treatment with BW720c.
The emerging paradigm for multistep carcinogenesis in epithelial malignancy is a long period of clonal evolution in histologically normal tissue [ 58], for which a substantial proportion of genetic alterations may occur during development [ 44].
The proportion of small alterations, such as base substitutions or small deletions/insertions and rearrangements, induced by C ions with LET of 30.0 keV μm-1 or 22.5 keV μm-1 is more similar to that induced by low-LET radiation (electrons) than that induced by C ions at 101-124 keV μm-1 LET (Table 4).
Additional deregulation of methylation at these sites suggests that a greater proportion of cells harbor alterations associated with an invasive phenotype.
Unfortunately, a substantial proportion of the sequence alterations identified during routine genetic testing are in-frame deletions/insertions, missense, silent, and intronic variants of uncertain clinical significance (VUS).
