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One limitation related to the simulation of the administration costs is the lack of information related to the proportion of inpatient administrations performed for docetaxel.
Additional analyses have been performed using a longer (3.0 months; five docetaxel injections) and a shorter (2.0 months; three docetaxel administrations) therapy time horizon, using varying estimates for the proportion of inpatient administration (high 75%; low 25%) and higher (+25%) and lower (−25%) cost estimates for each adverse event.
From the synthetic dataset generated, we estimated the proportion of total administration costs that is due to Pc or PAc for our sample of biologic drugs (categorized according to their respective routes of administration) by graphing a log-log plot of Pc versus PAc.
In general, we can say that a higher proportion of the administration costs of biologic drugs given subcutaneously or intramuscularly come from the proximal costs incurred before or after drug administration while for intravenous products, costs are incurred in both cost centres.
The proportion of intravenous administration tended to increase from 29 to 36% over time.
Our findings suggest that a significant proportion of IV administration errors reflect knowledge and/or skill deficiencies, with errors reducing in the first few years of clinical experience.
The proportion of area under administration is 9,650 km2, which is the milli of national territorial area.
Considering only the most important decision for each death, the proportion of cases with administration of medication to deliberately hasten death does not change (0.8% of all deaths).
Also, in a large proportion of patients drug administration was initiated well after 48 hours of organ dysfunction suggesting that DrotAA was sometimes used as a rescue therapy.
This implies that a degree of back-ground information from combined population surveys with regard to the proportion of differing routes of administration are required before accurate sewage measurements are feasible.
The development of resistance in P. aeruginosa may account for a proportion of clinical failures following administration of standard therapeutic regimens.
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