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The proportion censored decreased from 10% to approximately 2.5% as the mean risk increased.
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During follow-up, the proportions censored owing to, respectively, switch to another antibiotic and hospital admission were 19% and 3% in courses with clarithromycin, 18% and 3% in courses with roxithromycin, and 18% and 2% in courses with penicillin V.
An important characteristic of our dataset was the high proportion of censored data.
We further found that an increase in sample size improves power when there is a high proportion of censored data.
It is helpful though to know what proportion of censored individuals were lost to follow-up before the end of the study (Clark et al, 2002).
Initial inspection of survival data revealed a higher proportion of censored data in the Asian patients in comparison with non-Asian for several cancer sites, including breast (69% censored data vs 52%, respectively).
In particular, to correct for potential bias from the varying proportions of censored survivors in the different groups, while bearing in mind the issue of ambiguity related to modelling assumptions that Black et al. [ 34] highlight, we used information from non-censored individuals to correct the value of utility assigned to censored observations.
Thus, the proportion of participants censored in each year was the same for cases and controls.
The largest series (2380 patients) identified factors based on univariate analyses and data containing a large proportion (57%) of censored patients (Storniolo et al, 1999).
During follow-up, the number of patients at risk decreased substantially since a large proportion of patients were censored after contralateral risk-reducing mastectomy or BC recurrence.
Although a high proportion of cases were censored by three years, this had limited impact on estimates as diagnoses of interest were most commonly recorded soon after symptom onset.
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