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In most bacterial phyla, a proportion bias is found in favor of one particular BY-kinase type, for example, there is only 1 CD-type versus 83 TAD-CD-type BY-kinases in Alphaproteobacteria (fig. 1).
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We originally reported 80% of fully informative microsatellite markers based on a mapped set of 20 markers [ 12], a proportion biased upward due to a stronger selection of polymorphic markers that was later revised to a more realistic 60 to 70% [ 15].
Given this small proportion, this bias is likely to have been small.
Intercodon base proportion was biased in that A was found most often at N4, second only to T in certain specific cases.
This proportion is biased towards the urban areas.
In addition, our study has revealed that due to wide variability in the proportions of biases across different ChIP-seq datasets, no single control dataset can effectively account for all biases, even within similar cellular conditions.
As the visuals suggest, only those models assuming fixed and precisely known cell-type proportions suffer from these high biases (Fig. 1c e), whereas for DSection, which assumes noisy cell-type proportion priors, this bias is absent (Fig. 1f).
The data also showed that there was improvement in accuracy over time with a lower proportion showing digit bias.
Based on patterns of spatial bias, proportion of alignment affected by LGT, directionality, and absence of association with MGE, we conclude that DCT is likely the predominant mechanism of LGT among M. canettii.
A proportion of this bias may be explained by selective constraint, in that sites that are polymorphic within GH1 may be under less selective constraint and thus more free to exhibit sequence divergence among paralogs.
Although we tried to be as comprehensive as possible in our search for studies, the funnel plot is quite skewy and indicates a significant proportion of publication bias, which limits the evidence found in this meta-analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com