Pre-exposure prophylaxis works for the partners of people with HIV in the global north.
But prophylaxis works, by definition, on the healthy.
Although I believe an argument can be made that a placebo-controlled trial was ethically justifiable because it was still uncertain whether prophylaxis would work, it should not be argued that it was ethical because no prophylaxis is the "local standard of care" in sub-Saharan Africa.
If only few people receive prophylaxis, their work loss can be less than half of the value without prophylaxis, especially if the fitness of the resistant strain is low.
Young people think they are invulnerable, Mr. Warren said, and pre-exposure prophylaxis may not work until slow-release products that provide protection for months are available.
He recovered well from surgery, was maintained on levetiracetam for seizure prophylaxis, returned to work, and continued follow-up with the medical oncologist and neurosurgeon.
If 10% of the population between 20 and 60 years of age take prophylaxis, the expected work loss varies from 0.1 day (x sus = 0) and 1.1 days (x sus = 1) for low fitness values, and it is about 2.2 days (irrespective of x sus ) for high fitness values.
Of note in our study is the fact that the one group deemed to be at higher risk those working on high-speed mail sorting machines was found no more likely to begin or continue on prophylaxis than persons working elsewhere in the facility.
As far back as at least 1990, it also knew that "post-exposure prophylaxis" ("pep") often works in humans — that is, that a victim of a needle stick or rape or unprotected sex who begins taking a short course of antiretrovirals within 72 hours can probably avoid infection.
As there was no preexisting institutional protocol dictating antifungal prophylaxis or diagnostic work-up of IFD in this population during the years studied, assignment to treatments and performance of diagnostic procedures were based on individual clinician's judgment.
