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Our findings suggest that any augmented prophylaxis approach to reduce early morbidity/mortality needs to cover multiple organisms.
These findings are of particular relevance to LMICs, as treatment with surfactant within the first two hours of life may reduce mortality while requiring treatment of a substantially smaller number of neonates than the prophylaxis approach.
The majority of expectant, healthy and high risk pregnant women or mothers of ELBW infants interviewed, preferred the prophylaxis approach in contrast to the widely adopted, physician-directed approach of only offering indomethacin therapy as a symptomatic treatment for a hemodynamically significant PDA.
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Such analyses may involve influence of antibiotic prophylaxis, surgical approach, choice of implant design, or other issues.
Nevertheless, even if our calculations underestimated the costs of prophylaxis, the "monitoring approach" resulted cost-effective.
In Brazil the rates of Gram-negative bacteremia in neutropenic patients are high [ 15], rendering quinolone prophylaxis an attractive approach.
More studies are required to define the optimal length of CMV prophylaxis and the approach, i.e. pre-emptive vs universal prophylaxis, in order to prevent low-viral replication of CMV.
The ring or blanketing prophylaxis strategy, an approach for delivering large amounts of antiviral drugs to people within a defined area surrounding a limited localized influenza outbreak, will greatly increase the overall use of Tamiflu in a region compared with earlier strategies that aimed to treat only clinically infected cases (Ferguson et al. 2006).
These data suggest that ZFP TF-driven enhancement of the endogenous anti-angiogenic defense system may provide a new approach for prophylaxis and treatment of neovascular diseases of the eye.
An evidence based approach to prophylaxis and therapy of invasive fungal infections depends on the knowledge of epidemiology and of risk factors for these infections, as well as on the appreciation of merits and limitation of the available clinical trials.
In conclusion, LDR could be considered as a novel approach for prophylaxis of cisplatin induced renal damage, also it augmented the nephroprotective effect of rutin via modulating the expression of inflammatory, oxidative stress and apoptotic mediators as well as histological changes in rats kidneys and hence might be valuable in improving the therapeutic index of cisplatin.
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