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Prophylactic headache medication was rarely used.
Little is known about adherence to prophylactic headache treatment.
Participants with prophylactic headache or other prophylactic pain medication were excluded (n=209).
Additionally, the intake frequency and an overuse of attack-aborting medications (analgesics and triptans), use of prophylactic headache medication and non-pharmacological treatments according the recommendations of the German Headache and Migraine Society [29, 30] were further follow-up parameters.
Exclusion criteria were as follows: use of any kind of daily medication including prophylactic headache therapy but excluding oral contraceptives; pregnancy or breastfeeding; excessive use of analgesics or alcohol; serious somatic or psychiatric disorders; ischaemic heart disease; a supine systemic blood pressure more than 160/90 or less than 110/75 mmHg at entry of study.
Participants whom during the RCT receive any manual interventions by physiotherapists, chiropractors, osteopaths or other health professionals to treat musculoskeletal pain and disability, including massage therapy, joint mobilisation and manipulation, 44 changed their prophylactic headache medicine or pregnancy will be withdrawn from the study at that time and be regarded as dropouts.
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Prophylactic pharmacological headache treatments can be classified into antiepileptic medications, antidepressant medications, antiserotonergic medications and antihypertensive medications, including both beta blockers and calcium-channel blockers.
There is only indication for pharmacological prophylactic treatment of headache in children if non-pharmacological treatment is ineffective and/or the headache attacks are frequent (more than 3 4 attacks per month), prolonged and/or so severe that they affect the quality of life and/or function level.
Furthermore, we excluded patients who had undergone pharmacological prophylactic treatment for headache in the 6 months preceding the study, subjects with a frequency of headache lower than one every two months and patients with primary headache attack in progress.
Participants who used any medications (including headache prophylactic drugs) or hormone therapy daily before participation were excluded.
She was diagnosed with migraine without aura and prescribed zonisamide 400 mg/day as a headache prophylactic agent.
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