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The effect on frequency and quality of life was comparable to improvements observed with prophylactic agents.
As with abortive therapy, costs vary widely among these prophylactic agents.
The detection of this mechanism would be highly interesting for the question how to develop specific migraine prophylactic agents.
These results enhance our understanding of HIV-1C biology, with implications for designing and testing therapeutic and prophylactic agents.
Patients who had failed to respond to more than 2 different prophylactic agents in the past and patients resistant to all acute migraine drugs were not included.
Three trials of comparisons with oral prophylactic agents independently reported no significant between group differences for a variety of diary data outcomes but meta-analysis was not possible.
The majority of clinicians in the survey considered the efficacy/safety profile of OBT-A more favorable than that of oral prophylactic agents.
OBT-A treatment was offered by 60.3% of the clinicians after the failure of more than 3 oral prophylactic agents (Table 3).
Based on these results, chlorhexidine-containing mouthrinses may be prescribed as non-destructive prophylactic agents on materials evaluated in the present study for orthodontic patients.
Further clinical studies are required to investigate the effect of chlorhexidine-containing prophylactic agents during orthodontic treatments and on other types of archwires.
Hence, flunarizine is considered a drug of first choice in migraine prophylaxis, and is used as first-line prophylactic agents in most European countries [44].
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