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The special properties of fluorine have been exploited successfully in many aspects of research on these amine oxidases.
The lower affinity of [F]FL2-b may be attributed to the electron withdrawing properties of fluorine from the N, N metal chelating center.
Although fluorine's ability to initiate unusual enzymatic reaction pathways involved in mechanism-based inhibition is well-known, FlK represents a rare example in which an enzyme exploits the unique properties of fluorine to enhance its reaction rate and to drive substrate selectivity.
The increasing prevalence and success of organo-fluorines have instigated enormous efforts over the past decades in developing methodologies for efficiently introducing fluorine into organic molecules, however the unique properties of fluorine make these chemical incorporations challenging, usually needing harsh synthetic conditions and giving rise to moderate chemo- or stereo- selectivity.
A major determinant of FlK specificity derives from its ability to take advantage of the unique properties of fluorine to enhance the reaction rate, allowing fluorine discrimination under physiological conditions where both substrates are likely to be present at saturating concentrations.
On the basis of its ability to exploit the unique properties of fluorine to achieve substrate specificity, FlK represents an ideal model system in which to query molecular recognition of fluorine and its influence on enzymatic reactivity in a naturally evolved protein ligand pair.
Similar(54)
Due to the general availability and favourable physical properties of fluorine-18, much effort has been directed to fluorinated compounds.
Combining comprehensive properties of fluorine-containing molecules and electrochromic conjugated polymers, the polymers reported here are proven to provide a new strategy to design novel electrochromic conjugated polymers.
Therefore, it is unlikely that the enhancement in stability derives from the self-segregating property of fluorine, as the hydrophobic core of the protein is not involved in fluorocarbon interactions.
Other substances worth searching for include superheavy elements with the chemical properties of boron, fluorine, manganese, beryllium, scandium, vanadium, lithium, neon, and thallium.
Properties of high fluorine based mold fluxes with different basicities and contents of CaF2, Na2O, and MgO were measured, respectively.
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