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It is also worth noting that the transition metal ion of Cr3+ may emit near-infrared persistent luminescence when the chemical composition and lattice defects of ZnGa2O4 are properly manipulated, which allows the material to have potential applications in the optical imaging of vascularization, tumor, and grafted cells [3 5].
In toto, these data strongly suggest that, if properly manipulated, the GITR/GITRL pathway could represent an interesting therapeutic target in quite distinct settings.
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