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Activated Neu1 hydrolytically cleaves α-2,3-linked sialic acid(s) from the receptor's ectodomain, the desialylation process allowing for the removal of steric hindrance and thus for proper receptor dimerization and activation of its signaling cascade networks within the cancer cell.
Moreover, the requirement of UIM-adaptor proteins for FcεRI endocytosis supports our previous pharmacological evidence that Ag-induced FcεRI ubiquitination might represent a signal for proper receptor internalization.
To determine whether RA influences to some protein or which protein is a proper receptor for the RA, docking simulations were conducted using candidate proteins.
Second, in our analyses, we selected regions having mean CFP and YFP intensities between 600 and 2800 to ensure the proper receptor levels.
Regardless of whether the functional receptor unit is a dimer or a monomer, our results clearly show the critical role of Grk6-CXCR4 receptor interaction for proper receptor function.
For instance, down-regulation of CNKSR2 in TDI chondrocytes may impair the crosstalk between MAPK and Ral pathways which is essential for proper receptor endocytosis, cytoskeleton remodeling and DNA synthesis [55].
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In IP kinase mutant cells, MLKL failed to oligomerize and localize to membranes despite proper receptor-interacting protein kinase-3 (RIPK3 -dependent phosphoRIPK3 -dependent
Both the hindrance of the mucin barrier and the limited number of proper receptors on the epithelial cells of the host restrict cross-species infection by influenza viruses [6], [20].
It is well known that B19 can only infect the cells that have the proper receptors to which the virus can attach.
Given that frequency facilitation is closely correlated with LTD [ 60] in vivo and since proper A1 receptor function is essential for mossy fiber plasticity [ 20], any modifications of A1 receptor function or transport inhibition might partly contribute to reduced basal synaptic transmission, reduced frequency facilitation and impaired LTD in pro-aggregant animals.
This result demonstrated that intact lipid rafts were required for proper elastin receptor signaling.
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