Its greatest asset, however, is its close proximity to proper countryside.
Our study has focused on the prediction and identification of novel protein motifs dependent upon C-terminal proximity for proper function.
Alanine substitutions of Cys124 and Cys152, residues indicated by homology modeling to be in close proximity and in the proper orientation for disulfide bonding, yielded reduced ASPA protein and activity levels.
We hypothesized that PtdInsP3 binding and membrane localization is not required for AKT phosphorylation and activation by PDK1 if the two proteins could be brought into proximity as stable complex with proper conformation by alternative mechanisms.
However, when the name is misspelled, we must rely upon other clues, such as inclusion in quotation marks, capitalization, proximity to a correctly spelled proper name, or proximity to a marker word such as "labeled".
Several short peptide motifs involved in protein sorting roles and dependent upon their proximity to the C-terminus for proper function have already been characterized.
Together, these categories include all the major events of genomic evolution at this scale, and the relative frequencies of these events provide insight into the importance of proximity and strand-wise arrangement to proper gene function and regulation.
The N atoms in the Pyridines donor groups are in suitable proximity of the central Ti cation for proper binding interactions [14 17].
NS3 catalytic activities depend on formation of a tight, non-covalent complex with the HCV NS4A protein, a cofactor mandatory for proper protein folding and stabilization of the protease in proximity of cellular lipid membranes (Lindenbach, 2013; Lohmann, 2013).
Alternatively, proper regulation of this set of genes may require physical proximity between transcription initiation factors and upstream regulators such as transcription factors and chromatin remodelers.
