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For proper export of jerdostatin, a secretion leader sequence was engineered at the protein's N-terminus.
Of these, Emp24 and Eclair are required for proper export of Wg from the endoplasmic reticulum (ER).
Mr. Abreu added that if Mr. Keshari "did commit a violation of U.S. law by not acquiring a proper export license, we'll deal with that".
Were the Rosetta Stone to appear on the art market without the proper export permits and documented provenance, Dr. Cuno says, a museum curator who acquired it would risk international censure and possible criminal charges.
Authorities were alerted in August 2013 that an Italian lawyer had the mandate to negotiate the sale of the painting, which was already in Switzerland without proper export licences.
Yet, if America can do a deal with Russia, China might be persuaded to trade upper limits on its nuclear forces and proper export controls in return for an American pledge to keep defences limited.
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If further studies determine these motifs directly contribute to either the cellular localization or, for STAM-1/2, proper ER export, this would provide support for the idea that ER export signals or their mimics can be used not only to facilitate ER export, but also to promote interaction with COPII vesicles to mediate specific antagonism of the secretory pathway.
It is possible that while mutant huntingtin can interact better with CRM1, the inherent reduced solubility of polyglutamine-expanded huntingtin prevents proper nuclear export.
Both slx9∆ and slx9-1 were synthetically lethal with yrb2∆, suggesting that Slx9 and Yrb2 functionally overlap to ensure proper nuclear export of 40S pre-ribosomes.
The N-terminus of pro-amphiregulin has been documented to be required for proper folding and export from the cell since deleted N-terminal pro-region completely abolished the release of amphiregulin [30].
The authors speculate that altering intracellular oxidation/reduction parameters may assist in the proper folding and export of these proteins.
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