Additionally, a plethora of studies have demonstrated that absence or disruption of proper cell-fate determinant function (Numb, Pros, Brat) results in an uncontrollable expansion of the neuroblast/progenitor pool, and heavy (or complete) depletion of neuronally committed cells [ 25, 26, 28- 31, 34].
Fgf8 mRNA, expressed in the caudal portion of the PSM as a P-A gradient [ 33, 50], was shown to correlate with determination of front caudal regression and to be determinant for proper somite size) [ 33].
Thus, we provide evidence that Foxi1 is necessary for expression of at least four subunits in three different epithelia and most likely is a major determinant for proper assembly of a functional vacuolar H+-ATPase complex at these locations.
An intricate interplay between Gag and PR is the primary determinant of proper HIV-1 maturation, which is exemplified by documented coevolution of PR and its Gag substrate.
Although for a long time, the C-terminal domain (CTD) has been deemed critically important [ 19, 20], it remains still unclear whether this is the primary determinant for proper binding to chromatin or whether the WHD needs to first recognize the intrinsic structural features of DNA at its entry and exit sites of the nucleosome.
A detailed understanding of the structural determinants underlying proper SR-BI/HDL alignment that supports the selective uptake of HDL-CE into cells remains lacking.
Collective evidences indicate that the flow properties of blood are among the main determinants of proper tissue perfusion and the alterations, which play significant roles in many disease processes [ 13– 17].
A critical first step in developing new approaches for promoting the selective uptake of HDL-CE requires a clear understanding of the structural determinants underlying proper SR-BI/HDL alignment via "productive complex" formation.
In particular, we have made explicit the connection between ring positioning and cell shape, but also the fact that in cytokinesis, precise ring positioning is crucial to ensure the proper segregation of fate determinants (Clevers et al., Nature Genetics, 2005; Sedzinski et al., Nature, 2011 for instance) What is the mechanism?
The surrounding environment has been shown to be determinant for the proper migration of both neural crest cells [34] and cephalic mesoderm [9] to fill the branchial arches.
γ-carboxylation of VKDPs is widely accepted to be determinant for their proper function, highlighting the importance of investigating γ-carboxylation status of GRP in humans.
