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Given their propensity to regulate numerous processes and target genes, it is no surprise that aberrant expression of miRNAs has been linked to numerous pathological conditions such as asthma, diabetes, kidney, neurodegenerative, and cardiovascular disease.
miRNAs have the propensity to regulate higher connected proteins.
Bioinformatic analyses indicate that miRNAs may have a general propensity to regulate transcription factors [ 78].
For proteins in special tissues, miRNAs that target a lower number of genes have the propensity to regulate commonly expressed proteins rather than tissue-specific proteins.
Based on the findings of [ 104], which determined that tissue-specific proteins have the propensity to interact with commonly expressed proteins, Zhu et al. further found that miRNAs which target a lower number of genes have the propensity to regulate commonly expressed proteins rather than tissue-specific proteins in the human PPI network.
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There's another problem as well: Germany's propensity for trying to regulate speech, both on- and offline.
Therefore, the composition and integrity of these regions also concur to the propensity of telomeres to regulate the expression, replication and recombination of adjacent regions.
Liang and Li subsequently revealed that miRNA propensity [ 103] to regulate certain biological processes may be due to the higher connectivity of proteins in the PPI network.
Previous studies examining TREM2-triggered phagocytosis had not examined whether prior cell activation altered the propensity of TREM2 to regulate microglial phagocytosis.
It has recently been reported that interacting protein pairs have a certain propensity to be regulated by the same miRNA [ 34].
Since the interacting pairs demonstrate stronger propensity to be regulated by sc-miRNAs than non-interacting pairs, we next asked whether there are some correlation between the propensity and the distance between two proteins in the network.
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