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Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoiesis that results in peripheral blood cytopenias and a marked propensity to progress to acute myelogenous leukemia.
MDS has a high propensity to progress to MDS-related AML (MDR-AML).
For example, human melanocytic nevi (moles), benign tumors that have a low propensity to progress towards melanoma, display several hallmarks of OIS.
It would be interesting to verify if this subgroup of LG tumors could have a more aggressive potential and a greater propensity to progress and invade.
Although clonal, MDS is considered a premalignant condition with a propensity to progress to AML when additional genetic abnormalities are acquired.
The myelodysplastic syndromes (MDSs) represent an heterogeneous group of clonal hematopoietic stem-cell disorders with a propensity to progress to acute myeloid leukemia (AML).
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This is particularly interesting to consider in light of their different propensities to progress to malignancy, and could have instructive implications for other cancers where one needs to determine which benign tumours will undergo malignant transformation.
New data on the biology of MBLs may help to better discriminate the subset of MBLs which are more likely to progress from those cases with no propensity to progression.
The propensity for tumors to progress and metastasize reflects not only the oncogenic mutations in the cancer cells but also dynamic interactions involving non-malignant cells in the tumor cell microenvironment.
In addition, HIV may modify the natural course of syphilis in these patients by modulating immunologic response to T. pallidum in a way that may increase the propensity of the disease to progress to neurosyphilis [14].
As indicated by the pronounced rightward shifts in the CT8 dose-response curves, TMDs with greater hydrophobicity and helical propensity are better able to progress to this state, presumably in kinetic competition with CT8.
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