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Analysis of RV and LV integration sites in human HSCs showed an RV-specific propensity to integrate into hot spots and to target genes involved in the control of growth, differentiation and development of hematopoietic cells [26], [27], suggesting that the gene expression program of the target cells is instrumental in directing RV integration.
Evaluation of the amount of GFP+ area overlapping with the GFAP+ area (Santos Silva et al., 2007), showed that STX-SC (Fig. 6D) had a greater propensity to integrate GFAP+ areas than Ct-SC (Fig. 6B), with high integration in 25% of animals in the control group and in 60% of the animals in the STX group.
A number of investigators have now demonstrated that murine leukemia virus (MLV) vectors have a propensity to integrate around transcription start sites (TSS) [8] with a higher than expected integration frequency within 2 introns of Mds1/Evi1 gene [5], which was previously identified as a component of MDS-EVI1 translocation 3∶21 found in human acute myelogenous leukemia (AML) [9].
The results show that the propensity to integrate is related to the appropriability regime, direct capabilities, financial resources, and synergies between the products.
At low levels of R&D intensity, firms' propensity to integrate their activities is low, but increases with escalating levels of R&D intensity in order to avoid the misappropriation of value generated by technological knowledge.
However, beyond a certain R&D intensity level, the propensity to integrate activities declines, since the level of technological knowledge is high enough to prevent imitation by third parties.
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The findings show that the level of Research and Development (R&D) intensity (representing the creation of firm specific technological knowledge) has an inverted U-shaped relationship with the propensity of firms to integrate activities within organizational boundaries.
Finally, we investigated whether the greater propensity of STX-GFP-Schwann cells to integrate and migrate in the CNS was correlated with PSA expression by the grafted Schwann cells.
Immediate transition fires once whenever its propensity function is different than 0. To further enhance the power of our method to integrate experimental data, we allow stochastic transitions to be delayed (Bratsun et al., 2005).
"I had to integrate it.
We may be failing to integrate Muslims.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com