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Because CML has the propensity to evolve from a chronic phase to accelerated phase and finally to blast crisis phase, one can pinpoint the phase and developmental stage at which mutations arise.
Knowledge of genetic architecture can inform us about the propensity to evolve (i.e. 'variability' sensu [2]) on all timescales.
Double pulses also occur in numerous other katydid genera [23], [31] suggesting that pulse pattern is a pliable trait with a propensity to evolve a double pulse structure.
The trade-off between groEL´s high conservation at the sequence and functional levels and its high propensity to evolve novel functions remains poorly understood.
Myelodysplastic syndromes (MDS) comprise a heterogeneous range of haematopoietic diseases characterised by bone marrow failure and a variable propensity to evolve into acute myeloid leukaemia.
By applying similar selection to both characters and using a comparative analysis we test whether the characters differ in their propensity to evolve independently among serial repeats.
Similar(54)
The propensity for phenotypes to evolve, or evolvability [ 8- 11], is determined by the capacity of genetic and developmental systems to produce heritable variation and the action of selection on those variants [ 12, 13].
Moreover, the short nature of many linear motifs means they have a high propensity to convergently evolve and emerge in unrelated proteins.
While many viruses have a natural propensity to acquire genetic material or proteins from the host cell upon formation of virions, others have by themselves evolved surface proteins for mimicry, e.g. the chemokine receptors of cytomegalovirus [3].
In addition, the propensity of Echo7 strains to evolve and the relationship between the prevailing Echo7 strain in mainland China and Wallace have not been studied.
To develop a statistical framework for measuring coevolution, we began by modeling the propensity for each amino acid to evolve at a site in a protein as a discrete random variable with 20 possible outcomes representing the 20 amino acids.
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