In some studies measurements of susceptibility before and after acquisition of each pTRM have been used to monitor alteration (e.g., Coe (1967a); Gonzalez et al. (1997)) or a propensity to alter has been inferred from differences in susceptibility on heating and cooling in temperature-susceptibility curves, with some studies using this as a pre-selection method (e.g., Hartmann et al. (2011)).
Using a modeled structure of the protein coded by the Sry1 locus (Sryα) interacting with DNA (cyan, Figure 5A), it can be seen that substitutions in amino acids 4, 21 and 76 (red, Figure 5A) may have a slight propensity to alter DNA binding stability and energy.
Trials such as RTOG 0825, which is presently open and evaluating newly diagnosed glioblastoma patients treated with standard external beam irradiation plus temozolomide versus standard external beam irradiation, temozolomide and bevacizumab, will address some of these concerns, although it may also point out the propensity of bevacizumab to alter glioma tumors to a more invasive phenotype.
'Epigenetic predisposition', is defined as an inherited propensity to an altered epigenetic state in normal tissues that confers a predisposition to disease.
Re-tuning one's strings between pieces would leave an instrument vulnerable to intonation problems, especially considering the propensity of gut strings to alter at the slightest change of climate.
Attaching them to proteins (via TG2) provides an elegant way to manipulate polyamine concentrations (organic cations) locally to be able to alter propensity for DNA (highly negatively charged due to phosphate backbone) to assume a compact (silenced) conformation.
Cyclin D acts via TGF-β-Smad signaling to alter the propensity for endoderm versus neuroectoderm fate.
The functional impact of these variants was therefore further assessed by their potential to alter disorder propensity, a known disease-mechanism, using PONDR, as was previously undertaken (20, 21) (Fig. 4).
There have been some successful attempts to alter the propensity of MuLV for T-cell lymphomas by using an EμMyc transgenic mouse, which results in predominantly B-cell lymphomas [231], and by expressing platelet derived growth factor B-chain (PDGFβ) from an MuLV-based retrovirus to generate mice with glioblastomas, which require activation of PDGF receptors for tumourigenesis [219].
Cumulatively they reveal secret passions, a myriad disappointments and a propensity for infidelity that will do nothing to alter the perception – right or wrong – that the French are a nation of philanderers.
Due to their propensity to self-assemble into an amphipathic protein membrane at hydrophilic-hydrophobic interfaces, and their ability to alter the hydrophobicity of their fusion partners, hydrophobins have been explored for purification purposes [ 23].
