The aggressiveness of the tumour is shown by its high propensity of organ invasion and metastasis to the brain, lymph nodes, liver, bone, leptomeninges, and also the bone marrow.
This eventually leads to formation of a thick multilayered granulation tissue, termed pannus, which has propensity for invasion at the interface of cartilage and bone, resulting in progressive joint and soft tissue destruction [ 3, 4].
Carcinoma in situ is an aggressive form of bladder cancer with a high propensity for invasion if left untreated.
Gastric cancer, the second leading cause of cancer-related death worldwide (Kamangar et al, 2006), is known to have a poor prognosis due to its marked propensity for invasion and metastasis.
It also exhibits a propensity for invasion to lymph nodes, hematogenous spread and capacity to implant on peritoneal surfaces [ 96].
Pancreatic adenocarcinoma (PDAC) is notorious for its abysmal propensity of early lymphatic invasion, liver metastasis, recurrence, and poorest prognosis.
The propensity of versican G3 to influence tumor invasion to bone and the mechanisms of G3 mediated osteolysis warrants ongoing studies.
The propensity of versican G3 to influence tumor invasion to bone and the mechanisms of versican G3 mediated osteolysis warrants ongoing study.
This increase in cell invasion was abrogated when fulvestrant was used in combination with estradiol (dotted bars) suggesting that an estrogen receptor antagonist can block the invasive propensity of thyroid cells.
Although ACC is thought to typically grow slowly, late occurrence of locoregional recurrence and distance metastasis is very common because of a propensity for perineural invasion.
