By using cell-based aggregation assays, we identified several novel variants of SOD1G93A with reduced aggregation propensity within mammalian cells.
Often, in corresponding disorder profiles, MoRFs are indicated as "dips"; i.e., regions with locally increased order propensity within long IDPRs.
The mediation analysis revealed that small world propensity within one intrinsic connectivity network supporting general intelligence, the dorsal attention network, was promoted by a pattern of monounsaturated fatty acids.
Moreover, substitutions of H4 and R5 did not affect the β-sheet propensity within the AChE586-599 seeuence (see Figure 1).
Thus, it appeared that H12 was more "important" than H4, which was in agreement with the significant loss of propensity for conversion to β-strand within the sequence YMVH (the strongest propensity within AChE586-599), wH12 H12 was mutated to Ala.
Given the PT values for each gene, we asked if interacting genes within the FOS-GRN share more similar propensity within themselves than with non-interacting components.
We conclude that, while both ADCYAP1 and CLOCK may correlate with migratory propensity within or among certain populations or species, previously identified relationships between migratory behavior and sequence variants cannot be easily generalized across taxa.
Our results suggest that the establishment of trait linkage between dispersal and the propensity of within-group cheating may be a general phenomenon promoting complex social organization and multicellularity.
Each patient newly treated with extended release nifedipine was matched to up to two patients newly treated with amlodipine, according to propensity score (within 0.2 SDs), age at cohort entry date (within 1 year), sex and year of cohort entry.
We then used a greedy matching algorithm to pair each patient receiving a statin with an untreated individual based on the logit of the propensity score (within 0.2 standard deviations), age at index date (within 2 years), sex, year of cohort entry, and presence or absence of diabetes.
