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The leap condition defines an upper bound for the size of each timestep τ: it must be so small that the propensities do not change significantly for its duration, i.e. the change in state from time t to t + τ is very small [ 10].
Assuming τ is sufficiently small so that the propensities do not change significantly during each step (the 'leap condition'), the number of reactions occurring during [ t, t+ τ), K j, is a Poisson random variable [ 11, 12] with parameter a j (x) τ.
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He was by trade a cooper, and though his father had impressed upon him the need for a good education, the sailing-obsessed Nicol admits that his "unsteady propensities did not allow me to make the most of the schooling I got.
These results indicate that regions of high intrinsic aggregation propensity do not give rise to aggregation unless at least partial unfolding takes place.
Popper has specifically applied propensities to single non-repeatable events (1957), and that suggests that the concept of propensity does not involve any essential reference to long sequences of events.
However, disgust propensity did not correlate with ratings in this group and all correlations were non-significant in the depression group.
Importantly, increased aggregation propensity did not result from higher abundance of the insoluble proteins in the mutants when compared to wild-type.
On the contrary MAX and BCL3, which have high individual propensity did not appear to form cooperative clusters among the included TFs.> -wrap-foot> TF-clusters obyained by the TGC algorithm at stage 2 TSS-distal sites.
However, we clearly identify mutants that in cell culture show aggregation propensities that do not fit with expectations for disease duration.
For the latter attempt, experimentally obtained helix propensity values were used [ 39] to select amino acid exchanges that result in altered helix propensity, but do not disturb other characteristics profoundly.
If the propensity scores do not have high validity (i.e., predict therapy accurately), the difference between the two groups is meaningless.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com