An FEM is a computer-based engineering model that calculates theoretical stresses, propagation of force, and shape changes to a structure under loads using thousands or even millions of individual elements whose individual responses are well understood.
Likewise, the propagation of force within tissues is parameterized by the distribution and the orientation of extracellular matrix (ECM) molecules.
The patent model for both the conventional hyrax and MARPE will allow for greater propagation of the forces to the surrounding nasomaxillary complex.
The notion of active propagation of mechanical forces across tissues via spatial gradients in myosin-II activation is supported by studies of epithelial sheet migration (Ng et al., 2012) and collective invasion of cancer cell clusters (Hidalgo-Carcedo et al., 2011), in which an asymmetric distribution of actomyosin contractility promote cell cohesion.
This class of mutants combines strictly confined effects (removal of two adjacent side chains) with complex long range effects (realignment of remaining side chains on either side of the deletion to new positions and localized underwinding of the helical structure), which may possibly be coupled with the propagation of stress forces to the N- and C-terminal anchoring points of the Bridge Helix.
Due to the resistance effect of the grain boundary to the propagation of dislocation, more force needs be applied to move the dislocations across a grain boundary and hence the increase of yield strength and cutting forces.
However, the propagation of uncertainty from force measurements through to the predicted derivatives and onward into motion performance predictions, is less well defined.
This paper presents a Monte-Carlo type approach for evaluating the propagation of uncertainty from force derivatives through to predicted performance parameters.
Based on the different mechanisms producing ventilator induced lung injury (for example, lung over-distension, concentration of mechanical forces, propagation of liquid-gas interfaces, cyclic recruitment of small airways and alveoli, associated biotrauma) and the variability of disease in humans, each patient will require an individualized form of "protective" ventilation.
