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We examined the effect of ACSVL3 knockdown on the orthotopic tumor propagating capacity of GBM neurosphere cells.
Amongst the surface markers studied, we have shown that CD44+ cells are enriched for tumor propagating capacity and CD44 is a potential CSC marker of NSCLC cell lines.
In acute myeloid leukemia, HIF-1α has been found overexpressed in a sub-group of cancer cells with leukemia propagating capacity and was shown to regulate leukemia stem cell maintenance.
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Experimental and clinical evidence has revealed that cancer cells are heterogeneous regarding tumor-propagating capacity and response to therapeutic drugs.
Aided by technological advances, scientists are investigating how populations might be altered by adding, disrupting, or editing genes or suppressed by propagating traits that reduce reproductive capacity (1, 2).
The initiating event of fibril formation is peptide misfolding, which leads to acquisition of the capacity to aggregate in an infinitely propagating fashion.
This limited capacity likely puts migrants at risk of propagating the spread of a pandemic virus.
However, isolates of the revertant TR7 strain derived from HR23 regained the capacity to propagate on either Trp or 4FTrp, in fact propagating faster on Trp than on 4FTrp (Mat et al. 2010).
These results suggest that a significant proportion of forecasted output response uncertainty, including forecasted storage capacity, is propagated from parameter uncertainties.
The value σ = 1 separates excitable media with capacity to propagate growing waves segments (σ>1) from those where only retracting waves segments (σ<1) occur.
Finally, although the precise cellular origin of splenic PrPd in TgOvPrP4 ovine transgenic mice still needs to be determined, our data suggest that this ovine transgenic mouse model properly reflects the behavior of the different TSE agents in sheep with regard to their capacity to propagate in the spleen.
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CEO of Professional Science Editing for Scientists @ prosciediting.com