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Orders for the 1970 proof specimens were not cut off until Dec. 31, 1969.
The State Department requested that the Mint make up presentation sets containing Proof specimens of each type of United States coin in circulation.
No Shield nickels were struck in 1877 or 1878, excepting proof specimens for collectors.
The mintage for 1876 was low (coining took place at Philadelphia and Carson City), and only proof specimens were coined in 1877 and 1878, at Philadelphia.
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The record holder for the denomination is a proof specimen of the 1864-L, of which there were an estimated 20 struck; it sold for $161,000 in 2012.
Then there's Graham ― a bulging, unsightly and very crash-proof specimen.
They also mention that a complete absence of air bubbles in the rock slabs is further proof that the specimen is authentic.
As proof-of-principle tissue specimens for labeling experiments, samples were derived from large solid tumors.
The authors apply this method to the analysis of amyloid plaques both in mouse tissue and in post-mortem specimens providing proof-of-principle of the reliability of the technique.
While evidence that a species was present at a given point in space and time is largely irrefutable (the specimen is the proof!), unambiguous evidence that a species is absent is more difficult to obtain.
Here, we used well-defined human CD33+ AML cell lines and genetically engineered sublines to test the impact of inhibitory (PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273)) and activating (CD80 (B7-1) and CD86 (B7-2)) T-cell ligands on the cytolytic activity of AMG 330 in vitro, and then conducted proof-of-principle studies in specimens obtained from patients with AML.
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CEO of Professional Science Editing for Scientists @ prosciediting.com