This model withstands molecular level proof-of-principle using both a model cell line and primary embryonic thymic organ cultures rendered transgenic by lentiviral transgenesis.
We present a proof of principle using the well-known CRP dataset, used by Bi (2007), Lawrence et al. (1993) and Stormo and Hartzell (1989), among others.
In a study of two cases, Tandon and Thomas were able to provide a proof of concept of using hollow, slotted nail with gentamicin cement beads.
A proof of concept of using iPS cell progeny in curing diabetes has been recently reported in a mouse system.
Although potentially useful resources for policy and practice, resources were not necessarily proof of use and we considered them to be the lowest level of impact.
If the M.L.B. considers Bosch's evidence, along with other information from its investigation of Biogenesis, as proof of use, it can proceed with those suspensions.
Real proof of use would be putting Civil's $5 million seed round to work, demonstrating user traction — then opening its offering to its crowd of passionate users.
Proof of use would have the added benefit of limiting the crowdfunding option only to companies that can actually attract users.
Proof of that traction would be financed by wealthy investors who can bear the risk; for the growing company, proof of use would open a new financing option and a better path to reward its early adopters.
