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Ki67 proliferation index and gamma-H2AX kinetic were carried out to demonstrate the feasibility and the proof of usefulness of 3DCM in hadron-biology and the impact of radiation quality on proliferation and DNA double strand breaks (DSBs) repair.
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All of these improvements are however beyond the current scope of our work, which focuses on providing proof of the usefulness of the proposed event representation as well as the interactive user interface.
Our aim is to provide a wide-breath proof-of-concept regarding the usefulness of GPU architectures to chemoinformatics, a class of computing problems still uncovered.
This work provides the proof-of-concept for the usefulness of this novel method based on the immunization of humanized mice for the rapid generation of human mAbs against a wide range of antigens.
The obtained results provided the proof-of-concept for the usefulness of this generic approach based on HIS mice combined with immortalization of human B cells for the rapid and inexpensive development of human mAbs against a wide range of antigens.
The chrX mutation sequencing project delivered proof-of-principle of the usefulness of this database (9).
"At the other extreme, there are uses that can be characterized as experimental, with little or no scientific proof of safety or usefulness.
Proof-of-concept studies verifying their usefulness were initially performed in animals.
Seitz and co-workers recently performed a thorough proof-of-concept study proving the usefulness of DNA as a template for creating precise multivalent architectures in a bottom-up approach.
We performed two proof-of-principle experiments to demonstrate the usefulness of this approach for functional gene analyses.
In keeping with a small molecule pharmacological approach, we describe here a novel screening strategy optimized for the detection of caspase-8 pathway-specific TRAIL sensitizers, and demonstrate its usefulness by a proof-of-concept screen.
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