Future studies should aim to determine actual proof-of-translation by raising antibodies against matreshkas, and probing cells or tissues where the mRNAs are known to be expressed.
Streptomycin is an antibiotic agent that binds to the 30S ribosomal subunit and interferes the initial selection and proof-reading steps of translation [43].
Treated muscles showed high levels of dysferlin expression with functional restoration with no evidence of toxicity or immune response providing proof of principle for translation to dysferlinopathy patients.
Small animal models as the rabbit are frequently used in articular cartilage research, but the model suffers from a high level of endogenous repair making the model best suited for proof-of-concept studies rather than clinical translation (Chu et al. 2010).
Results provided herein, highlighting the different response of mice with different genetic backgrounds, make the translation of these proof-of-concept studies more difficult.
Other cardioprotective drugs such as cyclosporine A, as well as other modalities such as remote ischaemic preconditioning, have undergone extensive preclinical testing and have now made the translation to small proof-of-concept studies and larger studies.
Our description of swine DC subsets and the transcriptomic work in progress, will lead to the determination of target antigens specifically expressed on swine DC subtypes, allowing the development of this technology in swine which, in addition to its great interest in animal health, would be an important proof of principle for its translation in human medicine.
In order to provide proof of concept data for translation of findings in preclinical models to the bedside, we have demonstrated that human regulatory T cells expanded ex vivo can protect human allografts (skin and vessels) from rejection [ 2, 3].
An extremely important step in the translation of cardioprotection is the conduct of small proof-of-concept clinical trials.
The choice of rapamycin for this "proof-of-principle" work was not arbitrary since the impact of this drug on translation initiation has been extensively studied.
The method of proof provides translations between PaL diagrams and sentences of monadic first-order logic.
