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The urine glucose testing provided a noninvasive inexpensive proof of severe hyperglycemia; nevertheless, the method was seriously limited by being only semi-quantitative, retrospective, and significantly dependent on the patient's individual threshold, detecting only concentrations above this threshold.
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But to some police officers, including some who knew him and some who did not, the episode was proof of the severe strain that the investigation had placed on some veteran officers, who could suddenly find their careers facing ruin and their reputations threatened.
Inhibiting IP-10 activity through the use of the monoclonal antibody, BMS-936557, demonstrated efficacy in patients who achieved high serum concentrations in this phase II, randomised, controlled, proof-of-concept study of moderate-to-severe UC.
Assessment of light perception is a subjective measure and not a fool proof test in the presence of severe media opacity secondary to dense vitreous hemorrhage, traumatic cataract, dense hyphema and corneal edema.
As a proof of concept, in less severe disease, no classical pathogens are observed by NGS or by culture and the same genera are dominating the lower airways' microbiome and the oropharyngeal community.
Anti-IP-10 therapy with BMS-936557 demonstrated a modest effect at inducing a response in patients with moderate-to-severe UC in this proof-of-concept study.
Although the proof-of-concept studies described above have shown promising results, deliberate inhibition of apoptosis during severe infections might have unexpected and undesired consequences.
A canonical example providing proof-of-principle of the impact of PK-PD approaches on clinical practice was that of fluoroquinolones for treatment of severe respiratory infections.
We provide proof-of-concept that combining as few as 3 biomarkers using simple schemes may be able to accurately predict outcome in severe malaria infection.
Proof-of-concept clinical study.
We conducted two proof-of-concept experiments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com