But scientists are encouraged by a proof of principle reported by Boehringer Ingelheim, a German drug company, at the American Association for the Study of Liver Diseases conference in Boston in November.
The method is based on a proof of concept reported by Pimestein et al. (2011) for the use of an internal soil standard (ISS), a concept adopted from the wet chemistry discipline.
Nonetheless, the proof of concept reported here univocally showed that the expression of anti-phage VHH by a LAB represents a novel tool to prevent phage infection.
The one setting in which the effect of RIC has been predominantly positive is in STEMI patients treated by PPCI with five proof-of-concept studies reporting cardioprotective effects with limb RIC applied at the time of PPCI [ 8, 15, 75, 82, 94].
We present a proof-of-concept report involving awake surgery for a temporodorsal tumor.
In our technical proof-of-concept report, we could demonstrate the feasibility of DTI in combination with cortical parcellation.
This is the first proof-of-concept report of a disposable electrochemical test for methamphetamine in undiluted saliva.
Shu et al. provided the first proof-of-principle report showing that modulating lineage-specifying forces can restore the pluripotency of mouse somatic cells [18].
After DRAG, all sialylated glycans were converted into neutral molecules that can be readily analyzed by positive mode MS. In this proof-of-concept report, MALDI-MS was chosen due to its simple procedure, strong tolerance to impurities, and single sodium-adduct ion species for each glycan, which simplifies the quantitative comparison.
A number of recent proof-of-concept experiments reported in [11, 14, 15] have demonstrated the feasibility of pixelated communication.
The present proof-of-concept study reports the construction of a whole-cell biocatalyst for the de novo production of ω-hydroxy octanoic acid.
