Sentence examples for proof of principle trial from inspiring English sources

We performed a pilot, randomized controlled, proof of principle trial investigating the feasibility and effects of an intervention combining physical exercise and pain coping skills training (PCST).

Thus, PP analysis of our proof of principle trial provides for the first time evidence for a superiority of a preventive anti-infective therapy over current standard therapy.

Therefore, in an early stage of drug development it could be favourable to test potential drugs in a short intensive proof of principle trial for selection purposes, using a small number of patients in which a large amount of data is collected.

A recent "proof of principle" trial has been completed using inflatable bag and valved mask technology.

The once daily administration of DRV/r (800/100 mg once daily) has been clinically evaluated as part of the proof of principle trial (TMC114-C207) and POWER trials in treatment-experienced patients as well as in treatment naïve patients as part of ARTEMIS trials.

The proof-of-principle trial objectives are: safety; dose selection and schedule of vaccination; and demonstration of proof-of-principle.

Now a proof-of-principle trial suggests a simple solution: GM pollen could contain an additional gene that would kill any weedy offspring.

In this proof-of-principle trial, we make no a priori assumptions about effect size since the methodology and setting is unique.

Therefore, the GIPS-III trial may be regarded as a proof-of-principle trial focused on the cardioprotective effects of metformin.

The present proof-of-principle trial showed a consistent pattern of cytokine reaction in UC patients treated with pazopanib and provided circumstantial evidences for the role of microenvironment as a framework of druggable targets in this disease.

Because the HMGB1-as-cytokine story is still less than a decade old, it probably will be several more years before any of these approaches for targeting HMGB1 will be tested in a proof-of-principle trial in human patients.