The homology between genomic signatures from blood and brain elicited by TBI provides proof of concept information for development of biomarkers of TBI based on composite genomic patterns.
Confirmation of this would provide proof of concept information that chronic lung diseases such as COPD and IPF may benefit from treatment with adenosine based therapeutics.
It provides proof of concept information that human COPD and IPF patients may benefit from adenosine-based therapeutics such as ADA enzyme replacement therapy or treatment with an A2BR antagonist.
These findings suggest that components of adenosine metabolism and signaling are altered in a manner that promotes adenosine production and signaling in the lungs of patients with COPD and IPF, and provide proof of concept information that these disorders may benefit from adenosine-based therapeutics.
The FAA representative will need to see proof of the information you provided on the application.
Third, the combinatorial, syntax-like, proof-theoretical aspects of information can be brought to this setting in various ways.
As this proof-of-concept study showed, information theory can help clinicians decide which lab tests are truly needed.
Recently, Rogers et al. (2009) put forward a proof-of-concept in which information incorporated to a probabilistic model provides better annotation (Breitling et al., 2013).
This study aimed to investigate arsenic-related urinary metabolome changes and identify dose-dependent metabolic biomarkers as a proof-of-concept of the information that could be obtained by combining metabolomics and targeted analyses.
He described it as a "beautiful proof of principle" that information could be transferred from one brain to another in real time — not by mind-reading or telepathy, but a transfer of what might be called the impulse to act.
"Increasingly we have techniques that can prove with mathematical certainty the proof of encryption that information has passed from one location to another, or it has been accessed by one member of staff or another for a specific purpose".
