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It should also be remembered that a clinical diagnosis of infected necrosis based on fever, leucocytosis and other markers of sepsis without substantive proof of infection of necrosis can frequently be incorrect, and in turn may lead to potentially unnecessary surgery [ 1].
Most studies did not describe the criteria of eligibility and the process of selection of participants in sufficient detail and employed only one diagnostic test as proof of infection.
This approach may be more diagnostically accurate; but often, clinicians in the ED act on a suspicion of infection since proof of infection may only develop over time in the inpatient setting.
These triggers included hospital admission (1/26), ICU admission (5/26), proof of infection (2/26), diagnosis of sepsis (5/26), onset of sepsis (14/26; 54%), onset of organ failure (3/24) and onset of septic shock (7/26) - the remaining two samples were from autopsy studies.
Latent syphilis is defined as having serologic proof of infection without symptoms of disease.
If a PCR test is positive, this means that the DNA of a microbe is present and is considered definitive proof of infection for virtually every other infectious disease known in medicine.
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These regimens were administered before definitive proof of infections and until the results of microbial investigation were available (de-escalation antimicrobial chemotherapy) [ 11].
However, T. b. gambiense midgut infection is not proof of mature infection, although it shows direct circulation of T. b. gambiense between humans and tsetse flies.
Considering the dismal prognosis of febrile neutropenic patients with LI not treated promptly with an appropriate antimicrobial regimen, it is recommended to start therapy on the basis of clinical, imaging and/or laboratory findings indicative of a particular infection in patients at risk for, but without proof of this infection.
However, to reliably prove that the encephalitis with normal CSF white cell count is caused by TBEV, a proof of TBEV CNS infection is needed besides the usual diagnostic requirements i.e., the evidence of a recent infection with TBEV denoted by the presence of specific serum IgM and IgG antibodies.
Unfortunately, we could only give molecular proof of viral infection in two of the HAU patients, as the remaining patients declined anterior chamber tap.
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