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Our proof-of-concept design demonstrates efficient in vitro MR imaging of the cancer cells, and enhanced delivery of an anticancer drug into the cancer cells with comparable treatment efficacy.
Finding a biomarker that achieves all of this would allow investigators to perform efficient proof-of-concept studies and allow regulators to guide companies through the drug development process.
These very encouraging results provide proof of principle that efficient multiexon-skipping can be achieved using adeno-associated viral (AAV) vectors encoding multiple U7 small-nuclear RNAs (U7snRNAs), offering therefore very promising tools for clinical treatment of DMD.
Proof Let the number of efficient solutions be finite.
In this proof-of-concept study we demonstrated efficient and straightforward generation of oncolytic adenoviruses with E1 and E4 driven by heterologous promoters.
In this proof-of-concept study we demonstrated efficient and straightforward generation of conditionally replication-competent adenoviruses with E1 and E4 genes driven by heterologous promoters.
Henry does not refrain, however, from presenting a posteriori proofs — in the order of efficient, formal and final causes — that nevertheless refer exclusively to the existence of God de complexo; in other words, to the truth of the statement "God exists" (Summa, art. 22, q. 4).
Many other cryptocurrencies operate on the same 'proof-of-work' principle - albeit on a far smaller scale - but more energy efficient alternatives like proof-of-stake are being trialled.
These data provide proof-of-principle that this simple and efficient high-throughput screen of a relatively limited compound library is able to yield candidate small molecule inhibitors of Group 2 capsule biogenesis.
This will ensure rapid and efficient transition from proof-of-concept studies into pivotal efficacy studies, thus maximising the likelihood of success.
Theorems 1 and 1 provide certain initial intuition on the structure of strategy proof and efficient SCFs for the case of interference coupled systems.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com