"[The] previous system was a proof-of-concept demonstrated in the lab".
The proof-of-concept demonstrated the utility of such a platform as a hypothesis testing (experimental purposes) and design optimization (commercial purposes, as during bioreactor concept selection phase) tool.
Clinical proof-of-concept demonstrated by the first-in-class MI bevirimat and reappearance of second-generation drug candidates with improved breadth and potency in clinical trials strongly suggest that in the near future multiple MIs can be approved and used for treatment of HIV/AIDS patients.
An initial proof-of-concept demonstrates that although a human lecturer is preferable, robotic and virtual agents may be viable alternatives if designed properly.
This work was necessary and provided in vitro proof-of-concept demonstrating both successful delivery and the antiviral potential of these novel anti-AIV vectors against AIV in an avian cell model.
As such, this is the first proof-of-concept demonstrating that using condition-specific data can improve codon optimization gene design over the traditional CUB methods.
This work constitutes a successful proof of concept demonstrating that nanobodies can be engineered to recognize RNA-related epitopes.
We present herein a first proof of concept demonstrating the potential of a protein nanopore-based technique for real-time detection of selected Gram-negative bacteria (Pseudomonas aeruginosa or Escherichia coli) at a concentration of 1.2 × 108 cfu/mL.
We propose this is an important proof of concept, demonstrating that bipotential tumor stem cells are essential in tumors where oncogenic ligand-receptor pairs are separated into different cell types, and suggesting that Wnt-induced molecular and fate plasticity can close paracrine loops that are usually separated into distinct cell types.
After initial preclinical studies that supported proof of concept demonstrating that antibodies directed against CTLA-4 could induce tumor regression, ipilimumab was developed clinically.
So far, in vivo proof of concept demonstrating that superior antitumoral activity using an HDAC-isozyme-selective inhibitor can be achieved is lacking.
