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Using a proof of concept criterion of {P(GMI ≥ 1) ≥ θ}, a simulation investigation found that a θ of 50%, for sample sizes between 20 and 30 patients, had type I error of ≤ 20% and a power to detect Von Hoff's 1.33 effect of ≥ 80%.
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Proof-of concept experimental results are provided.
In a proof-of-concept study with multiple endpoints, criteria can be established for evidence of efficacy and for choosing a dose.
Therefore, using NF-YC as the bait protein fulfilled our criteria for good proof-of-concept screening material.
It might be possible in a proof-of-concept study for more than one dose group to satisfy the criterion demonstrating potential efficacy.
This research addresses these gaps through developing a methodology and proof-of-concept tool that integrates energy databases with visualisation systems and multi-criteria analyses.
Now, an appropriate phase 2 proof-of-concept RCT investigating beta 2 antagonism in acute respiratory failure with strict eligibility criteria would be an appropriate approach to define the role of beta-blockers in acute respiratory failure.
Our study is unique in being the first randomised controlled proof-of-concept intervention trial to investigate the feasibility of adding the biomarker proADM to established and guideline-recommended clinical criteria for site of care decisions in patients with LRTIs.
In this proof-of-concept study, we tested the feasibility, possible effects and limitations of adding proADM to CURB-65, and clinical stability criteria and biopsychosocial scores (SPI and PACD) for initial risk stratification and subsequent clinical management for LOS.
It was a proof-of-concept issue.
(Below, an iPad proof-of-concept app).
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CEO of Professional Science Editing for Scientists @ prosciediting.com