For this proteome step, only few patient samples were included being a critical point of the study but our volume based proteome-method represents a proof-of concept confirmed by the fact that we did not identify blood-derived proteins.
We added NP intralesionally, as proof of concept confirming the powerful potential of this delivery system as a targeted approach to deliver bioactive molecules for in situ myelin repair.
This proof-of-concept study confirmed the reliability of the DPC-1 orthotopic model for molecular imaging and recapitulating in large dogs the advanced form of human disease.
These proof-of-concept images confirmed that the microscope setup, acquisition software, and image processing code could adequately image MMC in thin sample volumes.
A small proof-of-concept study confirmed the effectiveness of a lock solution combining minocycline and ethylene-diamine tetraacetic acid on infection rates and prolonged catheter survival as compared with heparin [ 46].
The first proof of concept study confirmed prevention of gastric cancer cell proliferation by the hERG K+ channel blocker cisapride.
Based on the pioneering idea that RTX might be of value in the treatment of seropositive RA, a proof of concept study confirmed its efficacy and safety in combination with MTX and thereby provided strong evidence for the role of B cells in this disease [ 1].
In the same way, numerous proof-of-concept researchers have confirmed the increasing of cellular tolerances through increasing the production of ethanol and glucose (Liu et al. 2010; Tan et al. 2016).
A proof-of-concept clinical study confirmed minimal interaction between high-dose silibinin and both midazolam and (S -warfarin (9 and 13% increaS -warfarinrespectively).
A number of proof-of-concept trials have confirmed that the experimental evidence can be translated into clinical practice with regard to postoperative markers of myocardial injury; however, this effect has not been ubiquitous.
"This study, as proof of concept, successfully confirms predictions about that pathway," says Gerald Kasting, a professor of pharmaceutics and cosmetic science at the University of Cincinnati.
