Proof of concept has been established for non-cellular glucose-responsive insulin delivery ('smart insulins') to release insulin from implants or circulating depots in proportion to circulating glucose.
As proof of principal has been established in Arabidopsis, interest has grown in translation of these oil traits in established oilseed crops.
Proof of principle has been established with the discovery of a peptide bacteriocin antibiotic with a high degree of specificity against C. difficile [ 9].
Proof of principle has been established in animal models of Sjögren syndrome and lupus, pointing to the need for translational research to develop clinical trials.
Proof of principle has been established using intramuscular, intravenous, intraperitoneal, and subcutaneous routes of delivery by in vivo and ex vivo methods (reviewed in [ 28]).
Now that proof of principle has been established in this robust and reproducible cell-based cytotoxicity assay, the compound collection is being expanded to include a greater number and diversity of compounds.
Section 91 of the Child Act 2001 provides a range of sentencing options that the courts can use to deal with a child when a proof of offence has been established.
Thus, the nature of the clinical study (e.g., phase I, II) and the extent to which the biomarker proof-of-concept has been established is taken into account when devising the validation plan.
The proof-of-principle has been established with islet transplantation in T1D 103 and pancreas transplantation for T2D.
Proof-of-concept has been established for sagopilone in platinum-resistant (Rustin et al, 2007a) and platinum-sensitive (McMeekin et al, 2008) ovarian cancer, melanoma (Wenk et al, 2008) and androgen-independent prostate cancer (Graff et al, 2008).
