Sentence examples for pronounced specificity from inspiring English sources
Modifications of the bis-indole included polar or acidic functionalities at positions 5′ and 6′ and a bromine or a trifluoromethyl group at position 7, affording analogues that possess high activity and pronounced specificity.
Since in vertebrates no polySia degrading enzymes exist, the molecule has a long half-life in the organism, but degradation can be induced by the use of endosialidases, bacteriophage-derived enzymes with pronounced specificity for polySia.
However, despite this diversity of signaling, MAPKs are characterized by a single pronounced specificity, namely a preference for phosphorylating proteins at a Ser/Thr-Pro motif [3].
Interestingly all of these genes do not show a pronounced specificity to any anatomical structure.
Remarkably, adoptively transferred CTLs that induce severe EAE in C3H mice (5) showed a pronounced specificity toward MBP82 90.
These tests confirm that A. candida races show pronounced host specificity to distinct host species.
In the stress exposed mice investigated here, there was pronounced strain specificity, i.e. 8 h after stress ADAM10 was strongly down-regulated in C57BL/6J mice (Table 3), but up-regulated in DBA/2J mice (Table 5).
Consistently with the colocalization results that pointed to pronounced tissue specificity, genes near Rnap2 and Rxrα binding sites are enriched for distinct biological functions across tissues, and these pathways largely reflect known processes in each tissue (Additional file 2: Figures S2 and S3).
We show that the neurexin repertoire displays pronounced cell-type specificity that is remarkably consistent within each type of neuron.
The study's results showed that the association between HP and AIP became more pronounced when the specificity of the definition of AIP was increased by lowering the diagnostic cutoff value.
Consistent with our hypothesis of a later origin of proteins with more specific functions, we find that older genes are on average more broadly expressed, while young genes tend to be tissue-specific, tissue-specificity is most pronounced for genes restricted to primates or mammals.
