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The more pronounced progression of cardiac dysfunction due to the concomitant renal dysfunction has also not been observed.
Patients were divided into two groups based upon the radiological progression per year of follow-up: group I with moderate progression (n = 20) (by <2 points/year, Larsen score) and group II with pronounced progression (n = 16) (by ≥ 2 points/year, Larsen score).
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Patients with MetS, in particular those with overt diabetes mellitus, are disproportionately affected by cardiovascular disease, compared with those without diabetes, due to a particularly pronounced atherosclerosis progression.
Angiogenic switch from laminin-9 and laminin-11 to laminin-8 and laminin-10 first occurs in carcinomas in situ and becomes more pronounced with progression of carcinomas to the invasive stage.
Similarly, in liver cirrhosis inflammation of the small bowel is notable [22] and becomes more pronounced with disease progression.
These features became more pronounced with disease progression and were accompanied by pannus invasion, cartilage damage and periarticular bone erosion in mice which had the disease for five weeks as verified from visual identification of joint swelling.
To test whether any effects of glycaemia progression were more pronounced with certain characteristics we tested for an interaction between the treatment effect on glycaemia progression and the characteristic concerned.
However, the differences between categories for the order of progression are less pronounced in large groups.
In contrast, the fusion protein showed a much more significant efficacy in suppressing the CIA progression, with a pronounced reduction in clinical score, paw swelling, joint damage, and cytokines expression at the same dosage as that of IL-1ra.
si752 yielded a more effective knockdown of E7 than did si198, and the effects on miR-15b expression and cell-cycle progression were more pronounced in si752 samples than in si198 samples.
This progression was not as pronounced after Tc-cad knockdown due to decreased germband length (supplementary material Fig. S5).
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