This limitation is more pronounced for markers with large minor allele frequencies.
The effects observed for TuJ1 are probably not so pronounced, because this marker not only labels postmitotic neurons but is also expressed in neuroblasts.
The advantage of the two-SNP/one-QTL over one-SNP/one-QTL model becomes more pronounced when the marker and QTL display weak disequilibria and when a small sample size is used (result not shown).
Likewise, a reduction in population size would also cause a depletion of genetic diversity by the action of genetic drift alone, which is more pronounced at mtDNA markers due to its lower effective size compared to nuclear markers (e.g [ 32, 54]).
While rather similar increases were noted in white blood cell counts, the response to marathon running was more pronounced in the markers of immune activation (suPAR, CD163) and the pro- (IL-8) and anti-inflammatory (IL-10) cytokines.
The problems associated with microsatellites highlighted in this paper may be less pronounced if more markers were typed, although they are unlikely to disappear completely as evidenced by the map inflation of the high density combined SNP and microsatellite maps, and by the previously undetected map inflation observed on the high density microsatellite-based chicken linkage maps [ 23].
Differences between the categories of albuminuria were most pronounced for the glomerular marker IgG (>30-fold increase from normoalbuminuria to macroalbuminuria) and the distal tubular marker H-FABP (>21-fold).
While the engrafted myoblasts showed no evidence of neural differentiation, a fraction exhibited pronounced coexpression of endothelial marker antigens.
Not to be upstaged, Odessa has installed a historical marker pronouncing itself the Bushes' "First Texas Hometown".
Pathophysiological alterations (e.g. functional and structural changes, release of neurotransmitters and inflammatory markers) are more pronounced in chronic headache and a link between headache frequency and chronification has been observed.
